Nucleosome DNA Bendability Matrix(C. elegans)
نویسندگان
چکیده
منابع مشابه
DNA bendability and nucleosome positioning in transcriptional regulation
The placement of nucleosomes along genomic DNA is determined by signals that can be specific or degenerate at the level of sequence; the latter signals are harder to find using conventional methods. In recent years, the development of sophisticated machine learning techniques that can extract subtle phased signals has improved our ability to distinguish between various classes of nucleosome-pos...
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Nucleosome DNA bendability pattern extracted from large nucleosome DNA database of C. elegans is used for construction of full length (116 dinucleotide positions) nucleosome DNA bendability matrix. The matrix can be used for sequence-directed mapping of the nucleosomes on the sequences. Several alternative positions for a given nucleosome are typically predicted, separated by multiples of nucle...
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Experimental data of the DNA cyclization (J-factor) at short length scales exceed the theoretical expectation based on the wormlike chain (WLC) model by several orders of magnitude. Here, we propose that asymmetric bending rigidity of the double helix in the groove direction can be responsible for extreme bendability of DNA at short length scales and it also facilitates DNA loop formation at th...
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A strong correlation between nucleosome positioning and DNA methylation patterns has been reported in literature. However, the mechanistic model accounting for the correlation remains elusive. In this study, we evaluated the effects of specific DNA methylation patterns on modulating nucleosome conformation and stability using FRET and SAXS. CpG dinucleotide repeats at 10 bp intervals were found...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Structure and Dynamics
سال: 2009
ISSN: 0739-1102,1538-0254
DOI: 10.1080/07391102.2009.10507255